Know Before You Go
There’s no public transportation available to get there. The only way is to rent a car in the closest city, Antofagasta, which is quite cheap regarding to the western renting prices. Cycle can be an option if you’re courageous and plan plenty of drinking water.
Take the highway #5 from Antofagasta (the famous and beautiful Panamerican), heading south. About 60 km from Antofagasta, take on your right the road B70 heading south again. Then, about 10 km later, take the B710 on your left, still plain south. B710 is a dirt road which will almost bring you on the planet Mars. Follow the B710 for about 70 km more and you will spot the VLT area entrance on your right.
Remember that the VLT is located in a very arid, desertic and isolated region, so take a lot of drinking water and avoid engine failures on the B710.