The Bloemen Route, or “Flower Route”, stretches 25 miles through prime Dutch tulip country as a result of “tulip mania,” the world’s first economic bubble.

Unsurprisingly, Holland is home to one of the most magnificent flower gardens in the world.

This historic hotel invented the chocolate brownie.

The "Greatest Sewer" of ancient Rome is one of the oldest sewer systems in the world, and is still in use.

In Florence's great Duomo, a 26 foot fresco honors a mercenary famous for attacking Florence.

The only museum with its curator—and her pets—buried inside.

An extensive collection of reliquaries containing the bones of saints housed in the largest Catholic church in Venice.

The small peaceful island off the Venice tourist circuit is where the city began more than 1,500 years ago.

A mysterious chasm in the heart of the ancient Roman Forum, the Lacus Curtius was once believed to be a gateway to hell.

Installed in an act of one-upsmanship, the annual sundial in this church is also a symbolic victory for the Gregorian calendar.

The oldest operating pharmacy in the world features 800-year-old recipes.

One of Catholicism's four major basilicas has a series of papal portraits that are said to predict the end of the world.

Museum dedicated to literary greats of the Romantic Period is also the home in which Keats met his untimely end.

2300-year-old Roman road connecting the empire.

The final resting place of the poets Shelley and Keats.

A master of trompe-l'oeil creates a stunning, tourist-fooling dome out of a flat ceiling.

Built to give thanks for the passing of a plague epidemic, this cathedral is a one-of-a-kind architectural hybrid.

Fittingly, America's museum of architecture is itself a magnificently designed old building.

The rose garden in Regent's Park where Pongo and Perdita met for the first time in Disney's "101 Dalmatians."

A statue marks the exact spot where The Boy Who Never Grows Up made his first literary appearance.

This intricately carved and hilariously huge bed was such a famous symbol both Shakespeare and Byron used it in their writing.

Children's hospital in London that operates on royalties received from Peter Pan, which J.M. Barrie signed over in 1929.

You'd never know the houses at 23-24 Leinster Gardens were fakes—until you see the train tracks on the other side.

A community of artists and entrepreneurs seeks a simpler life on London's waterways.