The oldest operating pharmacy in the world features 800-year-old recipes.

An Italian crevasse filled with abandoned buildings gives visitors a look at the world without humans.

This private skyway is filled with art and was expanded explicitly so that Hitler could appreciate a river.

This ancient Roman prison is decorated with an upside-down cross not as blasphemy but as saintly tribute.

Fountain where visitors can earn a license to be mad.

A unique Tuscan hideaway acts as an art mecca as well as a hotel.

Geothermal waterfalls in Tuscany.

The Vatican's secret porn-festooned bathroom was painted in erotic murals by one of the greatest artists of the Renaissance.

The Pope’s secret escape route.

Installed in an act of one-upsmanship, the annual sundial in this church is also a symbolic victory for the Gregorian calendar.

A mysterious chasm in the heart of the ancient Roman Forum, the Lacus Curtius was once believed to be a gateway to hell.

This Roman arch marks the location of an ancient gate at one of the Seven Hills of Rome.

An alchemist's "magic door" stands in the middle of a Roman park.

The engineering wonder and pleasure dome of a much-maligned emperor still holds undiscovered secrets.

This ritzy Italian market is built around a statue of an unforgiven heretic who was burned for his belief in an endless universe.

A hospital where antique dolls are given new life.

Hundreds of lucky felines haunt the ruins where Caesar was murdered.

Five candy-colored villages on the Italian Riviera.

This former Roman Catholic Church still contains the embalmed hearts and organs of 22 popes.

Filled with goldfish swimming in a shallow pool of sea water, this ancient crypt is more wishing well than burial site.

A fairy tale castle in modern Rome.

The only "Egyptian" pyramid in Europe and the legendary tomb of Remus.

Architectureal fantasy quarter of Rome.

This delightful little museum is dedicated to only one thing: pasta.