Every Easter, a small Sicilian town builds a stunning cathedral out of bread.

Brass cobblestones mark the places where individual Holocaust victims were taken from their homes.

More sculpture than building, this architecturally significant temple was built on the spot of Saint Peter's crucifixion.

This ritzy Italian market is built around a statue of an unforgiven heretic who was burned for his belief in an endless universe.

Jesus' footprints and the first catacombs in the world.

The underground sanctuary of a mysterious ancient cult.

This hidden Art Nouveau courtyard is an opulent feast for the eyes.

Rome's semi-secret peephole vista is also a former Crusader stronghold.

A master of trompe-l'oeil creates a stunning, tourist-fooling dome out of a flat ceiling.

In a city that boasts four separate inclined cable railways, this is one of the busiest funicular lines in the world.

More than 450 years ago, an Italian nun became the first woman to paint the iconic subject.

The largest and most famous wax anatomical collection anywhere in the world.

This private skyway is filled with art and was expanded explicitly so that Hitler could appreciate a river.

The oldest operating pharmacy in the world features 800-year-old recipes.

The doodles of a genius line the walls of a secret room under the Medici Chapel, where they were hidden for nearly 500 years.

A long-buried ancient ruin unearthed right in the middle of the city.

Every day is like Christmas on this street where the traditional Neapolitan nativity scene comes to life.

This cathedral hides a sculpted dog that determines your fate and an unexploded shell from World War II.

Buried next to Pompeii, this lesser-known Roman villa was the opulent vacation home of Emperor Nero's wife.

Erotic art covers the walls of the largest ancient pleasure palace.

Drink wine handed out through a window as part of an age-old tradition.

Some say this medieval church is where the poet Dante married his wife and also met the love of his life.

This amazingly well-preserved villa just outside Pompeii boasts rare examples of ancient Roman paintings.

A dead saint, a deadly poison, and a mysterious holy ooze.