The John Snow Memorial marks the epicenter of London's 1854 cholera epidemic.

An enormous, inside-out glass globe built in 1935.

This Boston medical museum features the skull of the famous medical case of Phineas Gage.

The American Revolution was galvanized into serious action due to the tragic clash with British soldiers that occurred at this location.

A former waterfront market is now in the center of town due to some interesting Boston engineering.

What was once a true peninsula has now been filled in, causing the water to recede and leaving many streetside "waterfronts" and landlocked "islands."