Know Before You Go
To reach the town, you have to hike in. There are two routes. One starts at a parking lot on Forest Service Rd in North Carolina; don't hike the gravel road, instead find a tiny path off to the right of the parking spot, strait up the mountain. Turn left at the top and walk till you find a sign for Lost Cove. Then walk down for hours. Watch out for bears.
The other route is flatter. From River Road, you hike three miles along the railroad tracks in Unicoi County, Tennessee that hug the Nolichucky River, until you reach a dirt road that you follow one mile up to the town. The GPS location is for the town itself. The tracks are live and to find the ghost town this way you have to walk along the tracks with a cliff strait up one side and a cliff strait down to a raging river on the other side a long way with no where to hide from a train and without being able to see around the corner. The train is slow and you can hear it from a long way away, but the steep hike through the bear sanctuary is probably a lot safer.