Site of the first pathological and bacteriological research facility in the United States.

A crumbling hospital from the 1850s on Roosevelt Island.

A grandiose octagonal home crowned by a large dome stands out among the antebellum mansions.

A 19th-century Gothic, castle-like statehouse by the Mississippi River.

This high-perched pachyderm marks the memory of not one, but two elephants gunned down in small New England towns.

This bar named after the world's first mixed cocktail was home to one of New Orleans' most notorious politicians.

Tiny historical streetcars wind through a small scale version of Crescent City in this whimsical train garden.

Beer lover's can-covered house.

America's most famous museum of medical oddities is home to the remains of Albert Einstein's brain.

Built by prisoners of war, the largest small-scale model ever built includes eight miles of tiny streams that now sit abandoned.

One of the only Florida forts to remain in the hands of the Union all through the Civil War still stands as a historic stronghold.

The last holdout of a pre-Civil War rebel who took the matter of slavery into his own hands.

A mysterious find dredged from Louisiana waters.

The ancient dwellings of the Puebloans, located in the cliffs of majestic mesas.

Strange red rock formations that have been attributed to a higher power for hundreds of years.

Air Force Academy Chapel made of 100 identical tetrahedrons works to inspire those of all religions.

When ecosystems collide in the arid Southwest.

The ruins of this abandoned fort now stand as a picturesque reminder of America's march West.

This popular pilgrimage site offers a hole filled with holy healing dirt.

Wedding chapel's mysterious spiral staircase said to be miraculously constructed.

This innocuous New Mexico storefront was once the secret jump-off spot for Manhattan Project scientists.

This southwest-styled home in Santa Fe claims to be the oldest house in America thanks to an ancient bit of foundation.

A small metropolis of Pueblo cave dwellings have been carved right into the hillside of this national monument.

The official atomic museum of the United States explores the explosive and productive history of a much maligned energy source.