North America's oldest quarantine facility was built in response to Philadelphia's 1793 yellow fever outbreak.

This restaurant offers a side of antiques, curios, and a bathroom chock full of owls.

This eccentric mansion museum holds a impressive collection of rare and automatic instruments.

Its vintage camera collection gives a snapshot of the past as viewed through a photographic lens.

America's first serial killer rests in anonymity.

This Old Testament garden features 100 plants from biblical times.

This church in Pittsburgh is home to the largest collection of religious relics in North America.

This might just be the TARDIS of bookstores.

In the bowels of a 19th-century brewery lurks a fine-dining restaurant offering an array of themed feasts.

North America’s largest collection of horological devices and home to a colossal clock with a dizzying array of features.

In this cemetery stands the country's first public crematorium.

The first of Lancaster's "rural cemeteries."

The home of possibly the least-loved U.S. president stands as a sort of unpopular Monticello.

The oldest farmer's market in America is so ancient it was approved by the King of England.

The oldest surviving presidential residence in the United States.

These medicine cabinet staples are part of the museum's collection of everyday objects.

One of Philadelphia's largest murals resides hidden under this bridge.

The humble field where the first Major League Baseball game was played.

America's smallest national park site is the former residence of exiled Polish national hero Thaddeus Kosciuszko.

Contrary to popular belief, this secluded statue doesn't represent Pennsylvania's founder.

A legendary boxing venue and ring featured in Rocky V.

The world's third-largest crystal sphere has sat in the Penn Museum since 1927 with the exception of one outlandish theft.

This museum boasts a bucket of teeth and tells the tale of a 20th-century dental circus.

The abandoned coal loading dock is a canvas for unsanctioned art.