A Nesting Doll of Churches.

Jesus' footprints and the first catacombs in the world.

The skull of the patron saint of lovers lies in the Basilica di Santa Maria in Cosmedin—maybe.

2300-year-old Roman road connecting the empire.

The only "Egyptian" pyramid in Europe and the legendary tomb of Remus.

The yawning maw of this pagan visage is said to bite off the hands of liars.

This hidden Art Nouveau courtyard is an opulent feast for the eyes.

The crypts of Capuchin friars decorated with the bones of over 4,000 friars, including an entire "crypt of pelvises."

A new sculpture calls attention to climate change in the centuries-old city it threatens.

An extensive collection of reliquaries containing the bones of saints housed in the largest Catholic church in Venice.

Go inside to really appreciate this 500-year-old technological masterpiece.

This community on a small Venetian island has taken to painting their houses in bright neon hues.

Renaissance hospital featuring a rotating door into which unwanted babies were dropped.

The famous sculptor left his mark on this Italian wall in an internationally protected example of street art.

The oldest operating pharmacy in the world features 800-year-old recipes.

A brutalist gem towering over the heart of Milan.

Artistic tombs, monuments, and a beautiful "Hall of Fame" lurk inside this cemetery.

A space dedicated to contemporary art and culture, co-chaired by fashion icon Miuccia Prada.

An ossuary built in 1210 to collect bones from the Ospedale Maggiore of Milan.

One of the world’s smallest bars, just 13 square feet, is brimming with speakeasy flair.

A Milanese café entirely designed by the American director Wes Anderson.

This giant middle finger statue sends an unambiguous message to Italy's bankers.

Once a 19th-century brasserie, this McDonald's exterior celebrates Alsatian design and the "King of Beer."

A historic observatory precariously perched at the "Top of Europe."