The oldest operating apothecary in the US has treated everyone from Thomas Edison to Mark Twain.

The name of this famed hospital was once a byword for the horrors of medical and psychiatric care.

Hidden in an ordinary Midtown building is a one-room museum dedicated to the greatest escape artist.

A room in New York City that contains 250 cubic yards of dirt worth a million dollars.

Become a prohibition rebel.

This little museum is built on a theater that was once a wildly elaborate speakeasy.

A miniature rainforest is growing inside of a Midtown Manhattan office building.

The oldest family-run luncheonette in New York, last renovated in 1948, still serves food and drinks the old-fashioned way.

New York's oldest magic store.

This abandoned subway station beneath the Waldorf-Astoria hotel is allegedly used to secretly transport presidents.

A dilapidated dock tells the story of Titanic's missed arrival.

Order scoops of pandan, lychee, and black sesame at this family-run institution.

A semi-scholarly approach to sex.

Not even a series of devastating fires could keep this odd castle in upstate New York from bouncing back.

A bar, burger joint, and arcade housed in a late 19th-century church building.

The floor-to-ceiling collection in an old factory is a unique alternative to stuffy galleries.

Eclectic architecture in the woods of New York.

The wooden octagon in which Huckleberry Finn and A Connecticut Yankee were born can still be visited in upstate New York.

A carriage house converted into what resembles an 11th-century English manor house

A historic home with ties to the abolition and suffrage movements.

The library of every book lover's dreams.

This collection started by a Cornell professor once held more than 600 human brain specimens, including the one that belonged to its founder.

Surprisingly aquamarine waters fill deep lakes formed at the end of the last ice age.

This peaceful gem in upstate New York was chosen as the future home of the 14th Dalai Lama's Library and Museum.