The "birthplace of insulin," where Sir Frederick Banting realized the hormone could save the lives of Type 1 diabetics.

A six-story treehouse offers spectacular views of New York's Finger Lakes region.

An off the grid woodland retreat that harkens back to days long forgotten.

This museum pays tribute to the largest group in the Iroquois Confederacy.

More than 350 million years ago, western New York was covered in a vast sea. Today, you can dig up the remains of the plants and animals that lived there.

A natural gas leak provides a flickering flame beneath a waterfall.

This two-room factory has been cranking out the musical signifier of zaniness for a century.

This edgy museum will whet your appetite for the industrial history of Western New York.

Town full of spiritualists, some of whom are mediums, is still in full swing after 130 years.

This manor in the woods memorializes one of the greatest birders of a generation.

A quirky collection of outsider art made from automobile parts.