The curiosities and wonders of pharmacy in a delightful historic building.

The oldest cemetery in New Orleans, resting peacefully for over 200 years now.

A 200-year-old bar in the historic French Quarter refuses to give up its place in history, nor its role in securing ours.

The sounds of the world's largest fully functioning pipe organ dazzle shoppers at a Philadelphia Macy's.

Ant sculptures march up the side of what used to be an iconic spot in punk rock lore.

This elaborate towering structure was once famed for its revolutionary height.

Yo, Adrian!

This charming colonial alleyway is one of the oldest continuously used residential streets in the U.S.

The first American department store, and home to the largest operating musical instrument in the world.

Dr Barnes' $25 billion private collection of art and arboretum.

An abandoned cemetery lies in ruins as the surrounding forest swallows it whole.

World's first "penitentiary," meant to be humane, drove men insane.

America's most famous museum of medical oddities is home to the remains of Albert Einstein's brain.

A Natural History and Science Emporium.

A grand New York post office that is home to mailman Santas, scraps of postal history, and a pneumatic mail system.

The saddest little diner in New York.

This Manhattan skyscraper is a reminder of the brief but glorious age of urban air taxis.

A forgotten relic from New York's bygone trolley system hides in plain sight under a bridge.

Manhattan and the Bronx have been playing tug-of-war over this former island neighborhood for more than a century.

The home of the first American-born saint is one of the only curved buildings in New York.

Monument to a forgotten NYC disaster that claimed the lives of 1,000.

This historic building housed the surviving crew members of the Titanic, who were left destitute after the wreck.

Manhattan's deadly West Side railroad, which killed hundreds of New Yorkers, is remembered by this simple plaque.

Rat sculptures try to infiltrate the Graybar Building in an architectural tribute to New York City's nautical history.