This sculpture perfectly models the molecular structure of a drug that was never produced.

A small side chapel in Santa Fe's basilica is home to the oldest statute of the Virgin Mary in North America.

This southwest-styled home in Santa Fe claims to be the oldest house in America thanks to an ancient bit of foundation.

These Pre-Columbian petroglyphs contain representations of birds, deer, hunters, and even some early Native flute players.

One man has carved a number of natural New Mexico caves into psychedelic sandstone temples.

An immersive environment that is part haunted house, part choose-your-own-adventure, and part jungle gym.

Anne Rice, one of the most influential writers in gothic literature, is buried alongside her husband in a New Orleans cemetery.

Striking images of New Orleans history, including colonizers, soldiers, Klansmen, scientists, sharecroppers, and more, are depicted in frescoes that line the walls of this transportation hub.

From a supper club to a gay bar to an HBO shooting location, this 125-year-old Victorian mansion has lived many lives.

Colorful, cheeky signs spill out of legendary New Orleans folk artist Dr. Bob's Bywater studio warning you to "Be Nice—Or Leave."

An architectural experiment in the Lower Ninth Ward, this row house is capable of floating as high as the Katrina floodwaters.

This city block-long devotional site, a replica of a famous site in France, is dedicated to the patron saint of grandmothers, mothers, and educators.

This cathedral dedicated to Louis IX, sainted King of France, holds many secrets.

Installed as a beacon of hope for a hurricane-racked island, the statue had to be moved multiple times due to the eroding coast.

Professional and amateur dioramas, taxidermy, and oddities all located in an attic above a gallery.

After serving in Vietnam, Korea, and even a stint in the Turkish navy, the unique ship is now open as a museum.

Taxidermied cartoon heads, unseen illustrations, and famous characters all reside in this small gallery space.

This ancient settlement contains some of the largest earthen mounds in North America.

Every year, a Louisiana town remembers a brief Civil War truce inspired by Masonic brotherhood.

This Louisiana folk art gallery is a gnarled collection of driftwood homonculi.

This creepy, yet oddly beautiful cemetery is home to one of the founding fathers of Lake Charles.

A miscalculation turns a very shallow freshwater lake into a very deep saltwater lake.

An artist weaves "wooden quilts" with scraps salvaged from his Katrina-damaged home in Tremé.

This 19th-century sugarcane plantation is one of the most well-preserved estates of its kind, including its original quarters for enslaved laborers.