The oldest operating pharmacy in the world features 800-year-old recipes.

The middle finger of modernity.

This strange bovine gargoyle is said to have been put in as a passive aggressive form of revenge.

An extraordinary house museum and cabinet of curiosities in the heart of Florence.

Legend says this mysterious stone head belongs to a woman who was petrified by an alchemist.

Overlooked amid the tourist bustle of Florence, this museum is dedicated to the craft of stone inlay.

The famous sculptor left his mark on this Italian wall in an internationally protected example of street art.

Nestled in the heart of Milan is a real wunderkammer of morbid curiosities.

Just across from the "Last Supper" painting is the famous painter's vineyard, a gift received for creating the masterpiece.

A space dedicated to contemporary art and culture, co-chaired by fashion icon Miuccia Prada.

The mark of the Devil's horns on a marble column in Milan.

Before there were doorbells this bronze ear was installed for visitors to announce their arrival.

The odd depiction of the Virgin Mary and baby Jesus is rooted in the Catholic Church's eradication of Catharism.

Milan's duomo is covered in beautiful carving including a curious "dinosaur-like" beast.

Venice's "Island of the Mad."

The only museum with its curator—and her pets—buried inside.

A large grotto built in the 16th century amidst Florence's famous Boboli gardens.

A painting in the historic Cathedral Basilica depicts Jesus and his disciples dining on a traditional Peruvian menu.

This delightful little museum is dedicated to only one thing: pasta.

The Victorian-era greenhouse is stuffed with tropical plants, and open 365 days a year.

One of the Seven Wonders of the Modern World holds the world's tallest metal staircase.

This giant middle finger statue sends an unambiguous message to Italy's bankers.

A Milanese café entirely designed by the American director Wes Anderson.

The remains of a paranoid inventor's hidden workshop lie in beautiful ruins amidst a Canadian park.