The marble facade hides a little-known medical museum with early surgical instruments and rare copies of canonical texts.

This community on a small Venetian island has taken to painting their houses in bright neon hues.

Originally a leper colony, the island is now an Armenian monastery that's home to an incredible manuscript library and eclectic museum.

Venice's "Island of the Mad."

Venice's island of the dead.

This Venice bookstore has resigned itself to constant flooding by keeping its books in bathtubs and boats.

A new sculpture calls attention to climate change in the centuries-old city it threatens.

The only museum with its curator—and her pets—buried inside.

A faux desert landscape in the middle of the jungle that sprouts oases during the rainy season.

Eduardo Kobra’s breathtaking 32,300-square-foot graffiti wall took over Rio’s Olympic Boulevard.

The largest open-air contemporary art center in Latin America is a unique experience in the Atlantic Forest.

Museum precariously perched on a massive yellow pillar.

A fantastical and futuristic temple of light built from nine monumental glass veils.

Massive rock sculptures formed during the time of the dinosaurs still stand undisturbed.

A vast landscape of craters created by meteorites.

These spectacular ruins were built by Spanish padres in the 17th century.

This magnificent abandoned hotel has long been haunted by its Nazi past.

One man's quest to collect artifacts from every aspect of human life has resulted in this eclectic Argentinian museum.

One of the oldest colonial buildings still standing in South America.

The design of the Palacio Salvo has been described as "a lighthouse on top of a building."

This beautiful example of neoclassical architecture is one of Uruguay's most treasured cultural gems.

The oldest café in Montevideo preserves its history as the city's bohemian hub.

This wonderful rock formation constitutes the first geopark in Uruguay.

Abandoned bull fighting ring, slowly falling apart in Uruguay.