This massive stained-glass masterpiece is thought to be the largest Tiffany dome in existence.

This morbid, delightful curiosity shop offers everything from animal bones to human teeth.

What's left of the ruins of the 1893 Columbian Exhibition, or World's Fair, also known as the White City.

This historic hotel invented the chocolate brownie.

A speakeasy takes on Chicago's drinking culture.

This whimsical Oz-themed park had a wonderful impact on the surrounding neighborhood.

This collection of neon icons is preserving Arizona's history, one sign at a time.

This public square capitalized on a single Eagles reference to bring some life back to an Arizona town.

A natural history wunderkammer in the middle of the desert.

In Tucson a giant metal snake helps pedestrians cross a busy highway.

This Route 66 classic sports a giant fiberglass rabbit that you can ride.

All of the 20 occupied houses in this mostly abandoned town feature some curious display of junk art.

The world's largest rose bush has literally outgrown the pioneer museum it was planted behind.

A classic Route 66 landmark that was built with scrap lumber and is held together with kitsch and puns.

The fading, forgotten remains of a once bright and booming factory.

Witnessing the might of this dessert-colored desert waterfall is a rare, powerful treat.

A stealthy Apache hideaway that became the haunting site of a mass grave.

This secluded aqua waterfall in the Grand Canyon is the perfect swimming hole, and the Havasupai tribe's fiercely protected natural wonder.

Dramatic river bend surrounds a natural red-rocked pedestal.

Most-visited and most-photographed slot canyon in the American Southwest.

This is one really big nut.

This fast-food outlet is the only space and UFO-themed McDonalds in the world.

A museum dedicated to the alleged Roswell Incident.

If drivers cross the rumble strip on this stretch of Route 66 at just the right speed it plays "America the Beautiful."